Oxycontin and Viekira

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ritonavir can increase the blood levels and effects of oxyCODONE. Contact your doctor if you experience dizziness, fainting, confusion, excessive drowsiness, slow heart rate, shallow or difficult breathing, and/or shortness of breath. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with ritonavir or lopinavir-ritonavir may significantly increase the plasma concentrations of oxycodone. The proposed mechanism is ritonavir inhibition of CYP450 3A4 and 2D6, the former of which is primarily responsible for the N-demethylation of oxycodone to noroxycodone and the latter of which is responsible for the metabolism of noroxycodone to noroxymorphone. Approximately 11% of oxycodone is also O-demethylated via CYP450 2D6 to oxymorphone, which is further metabolized to noroxymorphone by CYP450 3A4. Increased oxycodone concentrations could conceivably increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In twelve healthy volunteers, coadministration of ritonavir (300 mg orally twice daily for 4 days) and oxycodone (10 mg orally one hour after the first dose of ritonavir on day 3) resulted in a 1.7-fold and a 3.0-fold increase in oxycodone peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to oxycodone administered with placebo. Coadministration of the same dose of oxycodone with lopinavir-ritonavir (400 mg-100 mg orally twice daily for 4 days) resulted in a 1.4-fold and a 2.6-fold increase in oxycodone Cmax and AUC, respectively. Both ritonavir and lopinavir-ritonavir prolonged the elimination half-life of oxycodone from 3.6 to approximately 5.5 hours, and reduced the AUC of the metabolites noroxycodone and noroxymorphone by over 50% and 75%, respectively. While ritonavir alone had no effect on oxymorphone, lopinavir-ritonavir increased noroxymorphone AUC by 2.7-fold. These pharmacokinetic changes were accompanied by enhanced self-reported oxycodone effects.

MANAGEMENT: Pharmacologic response to oxycodone should be closely monitored during coadministration with ritonavir or lopinavir-ritonavir, and dosage adjustments made accordingly if necessary. Patients and/or their caregivers should be advised to seek medical attention if potential signs and symptoms of toxicity occur such as dizziness, confusion, fainting, extreme sedation, bradycardia, slow or difficult breathing, and shortness of breath.

Oxycontin

Generic Name: oxycodone

Brand name: Oxaydo, Oxycontin, Oxyfast, Roxicodone, Xtampza ER, Oxycontin, Oxecta, Roxybond, Xtampza ER; oxycodone is also present in the following combination drugs: Combunox, Endocet, Endodan, Moxduo, Oxycodan, Percocet, Percodan, Primlev, Roxicet, Xartemis XR, and others, OxyIR, Roxybond

Synonyms: OxyContin

What is Oxycontin?

Viekira

Generic Name: dasabuvir / ombitasvir / paritaprevir / ritonavir

Brand name: Viekira XR, Viekira Pak

Synonyms: Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets, and Dasabuvir

What is Viekira?