Paclitaxel and Sarecycline
Determining the interaction of Paclitaxel and Sarecycline and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Sarecycline may increase the blood levels and effects of PACLitaxel. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with sarecycline may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, kidney, and/or liver due to inhibition of P-gp-mediated efflux by sarecycline. When the probe P-gp substrate digoxin was coadministered with a single 150 mg dose of sarecycline, digoxin peak plasma concentration (Cmax) increased by 26%.
MANAGEMENT: Caution is advised when sarecycline is used concurrently with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sarecycline is added to or withdrawn from therapy.
- "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
Generic Name: paclitaxel
Brand name: Onxol, Taxol
Synonyms: PACLitaxel (Conventional)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Paclitaxel-Sarecycline Hydrochloride
- Paclitaxel-Sargramostim
- Paclitaxel-Sargramostim Intravenous
- Paclitaxel-Sargramostim Powder for Injection
- Paclitaxel-Sargramostim Solution for Injection
- Paclitaxel-Sarilumab
- Sarecycline-Paclitaxel (Conventional)
- Sarecycline-Paclitaxel Concentrate Injection
- Sarecycline-Paclitaxel Intravenous
- Sarecycline-Paclitaxel Novaplus
- Sarecycline-Paclitaxel protein-bound
- Sarecycline-Paclitaxel protein-bound Intravenous