Paclitaxel protein-bound Intravenous and Tacrolimus Extended-Release Capsules
Determining the interaction of Paclitaxel protein-bound Intravenous and Tacrolimus Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using tacrolimus together with PACLitaxel protein-bound may increase the blood levels and effects of one or both medications. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of sirolimus or tacrolimus with other drugs that are also metabolized by CYP450 3A4 may result in elevated plasma concentrations of the macrolide immunosuppressant and/or the coadministered drug(s). The mechanism is decreased drug clearance due to competitive inhibition of CYP450 3A4 activity. Although clinical data are lacking, the possibility of prolonged and/or increased pharmacologic effects of the drugs should be considered.
MANAGEMENT: Pharmacologic responses and/or plasma drug levels should be monitored more closely whenever a macrolide immunosuppressant or another substrate of CYP450 3A4 is added to or withdrawn from therapy, and the dosage(s) adjusted as necessary.
- "Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
- "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: paclitaxel protein-bound
Brand name: Abraxane
Synonyms: Paclitaxel protein-bound, PACLitaxel (Protein Bound)
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Paclitaxel protein-bound Intravenous-Tacrolimus Extended-Release Tablets
- Paclitaxel protein-bound Intravenous-Tacrolimus Granules for Suspension
- Paclitaxel protein-bound Intravenous-Tacrolimus Injection
- Paclitaxel protein-bound Intravenous-Tacrolimus Intravenous
- Paclitaxel protein-bound Intravenous-Tacrolimus oral and injection
- Paclitaxel protein-bound Intravenous-Tacrolimus Oral, Intravenous
- Tacrolimus Extended-Release Capsules-Pacnex
- Tacrolimus Extended-Release Capsules-Pacnex LP
- Tacrolimus Extended-Release Capsules-Pacnex MX
- Tacrolimus Extended-Release Capsules-Pain Enz Topical
- Tacrolimus Extended-Release Capsules-Pain Relief PM Extra Strength
- Tacrolimus Extended-Release Capsules-Pain Reliever Plus