Paclitaxel protein-bound Intravenous and Tegretol XR
Determining the interaction of Paclitaxel protein-bound Intravenous and Tegretol XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CarBAMazepine may reduce the blood levels of PACLitaxel protein-bound in some patients, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Theoretically, coadministration with drugs that are inducers of CYP450 2C8 and/or 3A4 may decrease the plasma concentrations of paclitaxel, which is metabolized by these isoenzymes.
MANAGEMENT: Clinicians should recognize the potential for interaction with drugs that induce CYP450 2C8 and/or 3A4 and monitor for evidence of reduced therapeutic response to paclitaxel during coadministration.
- Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847
- Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993
- "Product Information. Abraxane (paclitaxel protein-bound)." American Pharmaceutical Partners, Schaumberg, IL.
- "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: paclitaxel protein-bound
Brand name: Abraxane
Synonyms: Paclitaxel protein-bound, PACLitaxel (Protein Bound)
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Paclitaxel protein-bound Intravenous-Tegrin Medicated
- Paclitaxel protein-bound Intravenous-Tegsedi
- Paclitaxel protein-bound Intravenous-Tekamlo
- Paclitaxel protein-bound Intravenous-Tekral Tablets
- Paclitaxel protein-bound Intravenous-Tekturna
- Paclitaxel protein-bound Intravenous-Tekturna HCT
- Tegretol XR-Pacnex
- Tegretol XR-Pacnex LP
- Tegretol XR-Pacnex MX
- Tegretol XR-Pain Enz Topical
- Tegretol XR-Pain Relief PM Extra Strength
- Tegretol XR-Pain Reliever Plus