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Pancuronium and Z-Clinz 5

Determining the interaction of Pancuronium and Z-Clinz 5 and the possibility of their joint administration.

Check result:

Pancuronium <> Z-Clinz 5

Relevance: 24.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pancuronium together with clindamycin topical may have addittive effects. You should be closely monitored for prolong breathing cessation and respiratory paralysis. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Lincosamides (e.g., clindamycin, lincomycin) have demonstrated neuromuscular blocking activity in vitro and may augment the pharmacologic effects of neuromuscular blocking agents. Clinically, the interaction has been reported in isolated cases involving atracurium, pancuronium, pipecuronium, succinylcholine, and tubocurarine. In one case, respiratory insufficiency was induced by the use of lincomycin in a patient recovering from blockade with tubocurarine. In another case, a patient developed prolonged neuromuscular blockade due to an unintentional overdose of clindamycin (2400 mg instead of 600 mg intravenously) shortly after recovery from succinylcholine and tubocurarine. Theoretically, the interaction may also occur with topically administered clindamycin due to systemic absorption, although no cases have been reported.

MANAGEMENT: Patients receiving neuromuscular blockers in conjunction with lincosamide therapy should be monitored closely during and after anesthesia for development of respiratory depression, and life support should be readily available if needed. Anticholinesterases and calcium may not completely antagonize the neuromuscular blockade induced by lincosamides.

References

Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Clindesse (clindamycin topical)." Ther-Rx Corporation, Bridgeton, MO.
Boolj LH, Miller RD, Crul JF "Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man." Anesth Analg 57 (1978): 316-21
"Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.
Avery D, Finn R "Succinylcholine-prolonged apnea associated with clindamycin and abnormal liver function tests." Dis Nerv Syst 38 (1977): 473-5
Fogdall RP, Miller RD "Antagonism of d-tubocurarine- and pancuronium-induced neuromuscular blockades by pyridostigmine in man." Anesthesiology 39 (1973): 504-9
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn, Kalamazoo, MI.
Alahdal O, Bevan DR "Clindamycin-induced neuromuscular blockade." Can J Anaesth 42 (1995): 614-7
Jedeikin R, Dolgunski E, Kaplan R, Hoffman S "Prolongation of neuromuscular blocking effect of vecuronium by antibiotics." Anaesthesia 42 (1987): 858-60
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Rubbo JT, Gergis SD, Sokoll MD "Comparative neuromuscular effects of lincomycin and clindamycin." Anesth Analg 56 (1977): 329-32
de Gouw NE, Crul JF, Vandermeersch E, Mulier JP, van Egmond J, Van Aken H "Interaction of antibiotics on pipecuronium-induced neuromuscular blockade." J Clin Anesth 5 (1993): 212-5

Pancuronium

Generic Name: pancuronium

Brand name:

Synonyms: n.a.

What is Pancuronium?

Z-Clinz 5

Generic Name: benzoyl peroxide / clindamycin topical

Brand name: Acanya, Benzaclin, DUAC, Neuac, Onexton, Z-Clinz 10, Z-Clinz 5, BenzaClin with pump, Duac Care System

Synonyms: n.a.

What is Z-Clinz 5?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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