Panitumumab Intravenous and Yuvafem local

• Generic Name: panitumumab
• Dosage Forms: n.a.
• Other Brand Names: Vectibix

Panitumumab injection is used alone or in combination with other medicines to treat metastatic cancer (cancer that spreads to other parts of the body) of the colon or rectum in patients who have already received other cancer treatments. Panitumumab injection should only be used in patients who have a wild type RAS (in both KRAS and NRAS) gene mutation test. This test helps the doctor decide whether the medicine will treat their cancer.

Panitumumab interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected by panitumumab, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, such as a skin rash, may not be serious but may cause concern. Some effects do not occur until months or years after the medicine is used.

Before you begin treatment with panitumumab, you and your doctor should talk about the benefits of panitumumab as well as the risks of using it.

Panitumumab will only be given by or under the immediate supervision of your doctor.

• Generic Name: estradiol topical
• Dosage Forms: vaginal tablet
• Other Brand Names: Estrace Vaginal, Estring, Vagifem, Yuvafem, Imvexxy

Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms (such as dryness, burning, and irritation). Other vaginal estradiol products are used for treating vaginal menopause symptoms and symptoms that affect other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is directly applied.

This medication guide provides information about Yuvafem for local treatment of vaginal symptoms of menopause (such as dryness, itching, irritation, and pain during sexual intercourse).

Yuvafem (local) may also be used for purposes not listed in this medication guide.