Panobinostat and Phenytoin Capsules
Determining the interaction of Panobinostat and Phenytoin Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may significantly reduce the blood levels of panobinostat, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of panobinostat, which is partially metabolized by the isoenzyme. The interaction has not been evaluated clinically, but simulations using physiologically-based pharmacokinetic (PBPK) models suggest an approximately 70% decrease in panobinostat systemic exposure.
MANAGEMENT: Concomitant use of panobinostat with potent CYP450 3A4 inducers should generally be avoided.
- "Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Panobinostat-Phenytoin Chewable Tablets
- Panobinostat-Phenytoin Extended-Release Capsules
- Panobinostat-Phenytoin Infatabs
- Panobinostat-Phenytoin injection
- Panobinostat-Phenytoin Intravenous
- Panobinostat-Phenytoin Oral Suspension
- Phenytoin Capsules-Panobinostat Lactate
- Phenytoin Capsules-Panocaps
- Phenytoin Capsules-PanOxyl
- Phenytoin Capsules-Panoxyl Soap
- Phenytoin Capsules-PanOxyl Wash
- Phenytoin Capsules-PanOxyl-4 Creamy Wash