Panobinostat and Xiaflex

• Generic Name: panobinostat
• Dosage Forms: n.a.
• Other Brand Names: Farydak

Panobinostat is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Panobinostat is used in combination with other drugs to treat multiple myeloma. Panobinostat is usually given after other cancer medicines have been tried without success.

Panobinostat was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, the medicine slowed progression of the disease. However, it has not been shown that panobinostat can improve symptoms or lengthen survival time.

Panobinostat may also be used for purposes not listed in this medication guide.

• Generic Name: collagenase clostridium histolyticum
• Dosage Forms: injection
• Other Brand Names: Xiaflex

Xiaflex (collagenase clostridium histolyticum) is made from a mixture of proteins derived from a certain bacteria.

Xiaflex is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Xiaflex is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.

Xiaflex is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking this medicine.