Panobinostat Lactate and Viramune XR
Determining the interaction of Panobinostat Lactate and Viramune XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nevirapine may reduce the blood levels of panobinostat. In some cases, this may make the medication less effective. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of panobinostat, which is partially metabolized by the isoenzyme. The interaction has not been evaluated clinically, but simulations using physiologically-based pharmacokinetic (PBPK) models suggest an approximately 70% decrease in panobinostat systemic exposure in the presence of potent CYP450 3A4 inducers.
MANAGEMENT: Caution is advised during concomitant use of panobinostat with CYP450 3A4 inducers. The potential for decreased efficacy of panobinostat should be considered.
- "Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: panobinostat
Brand name: Farydak
Synonyms: Panobinostat
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Panobinostat Lactate-Virasal
- Panobinostat Lactate-Virasal Topical
- Panobinostat Lactate-Viravan P
- Panobinostat Lactate-Viravan PDM
- Panobinostat Lactate-Virazole
- Panobinostat Lactate-Viread
- Viramune XR-Panocaps
- Viramune XR-PanOxyl
- Viramune XR-Panoxyl Soap
- Viramune XR-PanOxyl Wash
- Viramune XR-PanOxyl-4 Creamy Wash
- Viramune XR-PanOxyl-8 Creamy Wash