Paricalcitol and Zykadia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of paricalcitol, which is partially metabolized by the isoenzyme. According to product labeling, pretreatment with the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 5 days) in healthy volunteers approximately doubled the area under the plasma concentration-time curve (AUC) and half-life of paricalcitol (administered in a capsule formulation) compared to administration of paricalcitol alone. MANAGEMENT: Caution is advised when paricalcitol is used with potent CYP450 3A4 inhibitors. Serum calcium and phosphorus levels should be monitored closely. If clinically significant hypercalcemia develops, the paricalcitol dose should be reduced or interrupted and support therapy administered. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Zemplar (paricalcitol)." Abbott Pharmaceutical, Abbott Park, IL.

MONITOR: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of paricalcitol, which is partially metabolized by the isoenzyme. According to product labeling, pretreatment with the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 5 days) in healthy volunteers approximately doubled the area under the plasma concentration-time curve (AUC) and half-life of paricalcitol (administered in a capsule formulation) compared to administration of paricalcitol alone.

MANAGEMENT: Caution is advised when paricalcitol is used with potent CYP450 3A4 inhibitors. Serum calcium and phosphorus levels should be monitored closely. If clinically significant hypercalcemia develops, the paricalcitol dose should be reduced or interrupted and support therapy administered.

Paricalcitol

Generic Name: paricalcitol

Brand name: Zemplar

Synonyms: n.a.

What is Paricalcitol?

Zykadia

Generic Name: ceritinib

Brand name: Zykadia

Synonyms: n.a.

What is Zykadia?