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Paroxetine and PCE Dispertab

Determining the interaction of Paroxetine and PCE Dispertab and the possibility of their joint administration.

Check result:

Paroxetine <> PCE Dispertab

Relevance: 11.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using erythromycin and PARoxetine. This can cause altered consciousness, confusion, poor muscle coordination, abdominal cramping, shivering, pupillary dilation, sweating, high blood pressure, and high heart rate. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The use of some macrolide antibiotics has been associated with increased blood levels of some selective serotonin reuptake inhibitors (SSRIs), resulting in excessive serotonergic effects or serotonin syndrome. The mechanism is inhibition of the CYP450 3A4 isoenzyme, which metabolizes SSRIs.

MANAGEMENT: In cases where both drugs are necessary, one could consider using a macrolide antibiotic that does not inhibit CYP450 3A4, such as azithromycin or dirithromycin.

References

Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6
Pollak PT, Slayter KL "Delirium probably induced by clarithromycin in a patient receiving fluoxetine - reply." Ann Pharmacother 30 (1996): 1200
Timothy P, Sketris IS, Mackenzie SL, Hewlett TJ "Delirium probably induced by clarithromycin in a patient receiving fluoxetine." Ann Pharmacother 29 (1995): 486-8
Tracy TS, Cupp MJ "Delirium probably induced by clarithromycin in a patient receiving fluoxetine - comment." Ann Pharmacother 30 (1996): 1199-200
Lee DO, Lee CD "Serotonin syndrome in a child associated with erythromycin and sertraline." Pharmacotherapy 19 (1999): 894-6

Paroxetine

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: PARoxetine

What is Paroxetine?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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