Paroxetine Oral Suspension and Phenobarbital Tablets
Determining the interaction of Paroxetine Oral Suspension and Phenobarbital Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concomitant administration of paroxetine and barbiturates may decrease serum paroxetine levels and half-life. The proposed mechanism is induction of CYP450 hepatic metabolism by barbiturates. The clinical significance is unknown. Patients should be monitored for clinical response and the dose adjusted if an interaction is suspected.
- "Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.
Generic Name: paroxetine
Brand name: Brisdelle, Paxil, Paxil CR, Pexeva
Synonyms: Paroxetine, PARoxetine
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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