Parsabiv and Sensipar

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using etelcalcetide together with cinacalcet may significantly decrease the calcium levels in your blood. It is not recommended to start etelcalcetide until 7 days after stopping cinacalcet. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor if your condition changes or if you experience symptoms of hypocalcemia (low blood calcium) such as numbness or tingling around your mouth, uncontrolled muscle movements, irritability, depression, irregular heartbeats, or any increased sensitivity. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Concomitant use of the calcimimetics etelcalcetide and cinacalcet may lead to severe, life-threatening, hypocalcemia. The proposed mechanism is additive reduction in serum calcium levels through binding and activation of the calcium-sensing receptor on the parathyroid gland. Significant decreases in serum calcium may cause paraesthesias, myalgias, muscle spasms, seizures, QT interval prolongation, and ventricular arrhythmia. Both medications given alone may lead to severe hypocalcemia requiring treatment with therapies to increase serum calcium levels.

MANAGEMENT: Concomitant use of etelcalcetide and cinacalcet is not recommended. At least 7 days should elapse when switching from cinacalcet to etelcalcetide, and the corrected serum calcium level should be at or above the lower limit of the normal range. In addition, the corrected serum calcium level should be measured within one week of initiation or dose adjustment of either etelcalcetide or cinacalcet and monitored approximately every 4 weeks. The manufacturer product labeling should be consulted for management guidelines in the event of a reduction in corrected serum calcium levels below the lower limit of the normal range and/or symptoms hypocalcemia. Patients should also be advised to contact their health care professional if they experience symptoms of hypocalcemia, such as numbness or tingling in the fingers, toes, or around the mouth, muscle spasms, twitches or cramps, seizures, confusion, and irregular heartbeats.

Parsabiv

Generic Name: etelcalcetide

Brand name: Parsabiv

Synonyms: n.a.

What is Parsabiv?

Sensipar

Generic Name: cinacalcet

Brand name: Sensipar

Synonyms: n.a.

What is Sensipar?