Paxil and Tagamet

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using PARoxetine together with cimetidine may increase the effects of PARoxetine. Contact your doctor if you experience nausea, vomiting, tremor, sweating, decreased urination, blurred vision, rapid heartbeat, confusion, aggression, and seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration with cimetidine may increase the plasma concentrations of paroxetine. The mechanism is inhibition of hepatic first-pass metabolism of paroxetine by cimetidine. In a study consisting of 10 healthy subjects, cimetidine (200 mg orally four times a day for 8 days) increased the area under the plasma concentration-time curve (AUC) of paroxetine (30 mg single oral dose) by 57%, with high interpatient variability. In another study with 11 subjects, cimetidine (300 mg orally three times a day for 7 days) increased the steady-state peak plasma concentration (Cmax) and AUC of paroxetine (30 mg/day) by 45% and 51%, respectively, with no change in the half-life or elimination rate constant. The clinical significance of these changes is unknown.

MANAGEMENT: During concomitant administration with cimetidine, the possibility of prolonged and/or increased pharmacologic effects of paroxetine should be considered, particularly in susceptible patients such as the elderly or debilitated. Pharmacologic response to paroxetine should be monitored more closely whenever cimetidine is added to or withdrawn from therapy in patients stabilized on their paroxetine regimen, and the dosage adjusted as necessary. Alternatively, other H2-receptor antagonists such as famotidine, nizatidine, and ranitidine may be considered, since they are unlikely to interact with paroxetine.

Paxil

Generic Name: paroxetine

Brand name: Paxil, Brisdelle, Paxil CR, Pexeva

Synonyms: n.a.

What is Paxil?

Tagamet

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet?