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Paxil and Tryptophan

Determining the interaction of Paxil and Tryptophan and the possibility of their joint administration.

Check result:

Paxil <> Tryptophan

Relevance: 15.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using tryptophan together with PARoxetine is generally not recommended. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: The concomitant use of serotonin reuptake inhibitors and tryptophan should be avoided.

References

"Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
"Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. Savella (milnacipran)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America, Lincolnshire, IL.
"Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC, New Haven, CT.
"Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals, Raritan, NJ.
"Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.
"Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories, Philadelphia, PA.
"Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Prozac (fluoxetine)." Dista Products Company, Indianapolis, IN.

Paxil

Generic Name: paroxetine

Brand name: Paxil, Brisdelle, Paxil CR, Pexeva

Synonyms: n.a.

What is Paxil?

Tryptophan

Generic Name: tryptophan

Brand name: Tryptan, Gleolan

Synonyms: n.a.

What is Tryptophan?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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