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Paxil CR and Phenytoin Capsules

Determining the interaction of Paxil CR and Phenytoin Capsules and the possibility of their joint administration.

Check result:

Paxil CR <> Phenytoin Capsules

Relevance: 07.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with PARoxetine can make either medication less effective. Talk with your doctor before using these medications together. You may a need dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor first.

Professional:

MONITOR: Hydantoins may induce the CYP450 metabolism of paroxetine and thereby decrease its therapeutic effects. Also, paroxetine may slightly induce hydantoin metabolism.

MANAGEMENT: Monitoring for evidence of reduced effects of both agents is recommended. Dosage adjustments may be necessary if an interaction is suspected.

References

Boyer WF, Blumhardt CL "The safety profile of paroxetine." J Clin Psychiatry 53 Suppl (1992): 61-6
"Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.

Paxil CR

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: n.a.

What is Paxil CR?

Phenytoin Capsules

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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