Paxil CR and Pravachol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using pravastatin together with PARoxetine has been found in some studies to increase blood glucose levels, particularly in patients with diabetes. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your blood glucose to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of paroxetine and pravastatin has been reported to increase blood glucose in some studies. The mechanism of interaction is unclear. In one study using data from three electronic medical record (EMR) systems, a group of investigators retrospectively evaluated 104 patients with diabetes and 135 without diabetes who had received the combination and found that mean random blood glucose levels increased significantly from baseline after initiating the combination. The average increase was 19 mg/dL overall and 48 mg/dL in patients with diabetes. Similar increases were not observed in patients receiving either drug alone or other combinations of statin and selective serotonin reuptake inhibitor (SSRI). Likewise, another group of investigators using data from a different EMR system reported an increase of 19 mg/dL in mean glucose level from baseline in patients receiving the combination. In a third retrospective database study, investigators found no difference in random glucose, fasting glucose, and glycosylated hemoglobin mean values between 65 patients who were prescribed paroxetine and pravastatin and 2084 patients who were prescribed other statin and SSRI combinations after adjusting for the covariates of age, gender, body mass index, and body weight. However, no comparisons with baseline values were performed.

MANAGEMENT: Caution is advisable during concomitant use of paroxetine and pravastatin, particularly in patients with diabetes. More frequent monitoring of blood glucose should be considered.

Paxil CR

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: n.a.

What is Paxil CR?

Pravachol

Generic Name: pravastatin

Brand name: Pravachol

Synonyms: n.a.

What is Pravachol?