PCE Dispertab and Quinidine Oral, Injection, Intramuscular

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using quiNIDine together with erythromycin. Combining these medications can increase the blood levels and effects of quiNIDine. This may increase the risk of an irregular heart rhythm that may be serious, as well as other side effects of quiNIDine such as dizziness, lightheadedness, nausea, vomiting, diarrhea, and visual disturbances. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if you experience headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, as these may be signs and symptoms of excessive quiNIDine levels. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of quinidine with some macrolide antibiotics (e.g., clarithromycin, erythromycin, troleandomycin) may increase the risk of ventricular arrhythmias including torsade de pointes and sudden death due to additive effects on the QT interval. In addition, the clearance of quinidine may be reduced. Data are available for erythromycin. In six healthy male volunteers, erythromycin 250 mg given orally four times a day reduced the median total clearance and peak plasma concentration (Cmax) of a single 200 mg oral dose of quinidine sulfate by 34% and 39%, respectively. The mechanism may involve enhanced absorption as well as reduced clearance of quinidine due to inhibition of both intestinal P-glycoprotein efflux transporter and hepatic/intestinal CYP450 3A4 isoenzyme by erythromycin. A case report describes a 74-year-old patient whose serum trough quinidine levels increased by 50% two days after starting erythromycin lactobionate 500 mg every 6 hours with ceftriaxone 1 gram daily. The patient later developed torsades de pointes arrhythmia when the erythromycin dosage was doubled and metronidazole was added. A 25% reduction in the quinidine dose was required, and erythromycin and metronidazole were subsequently replaced with doxycycline and ciprofloxacin. Another case of torsades de pointes, followed by cardiac arrest, was reported in a 95-year-old patient receiving quinidine and erythromycin orally.

MANAGEMENT: The use of quinidine in combination with macrolide antibiotics should be avoided. Patients treated with these agents should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath, or syncope.

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

Quinidine Oral, Injection, Intramuscular

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: Quinidine, QuiNIDine

What is Quinidine Oral, Injection, Intramuscular?