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PCE Dispertab and Tagamet HB

Determining the interaction of PCE Dispertab and Tagamet HB and the possibility of their joint administration.

Check result:

PCE Dispertab <> Tagamet HB

Relevance: 03.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using erythromycin together with cimetidine may increase the effects of erythromycin. Contact your doctor if you experience nausea, vomiting, diarrhea, stomach pain, or hearing loss. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of cimetidine and erythromycin may result in higher-than-normal plasma levels of erythromycin through inhibition of CYP450 metabolism by cimetidine. One small study has reported an increase of 73% in the area under the plasma concentration-time curve. Bilateral hearing loss occurred in one patient who had renal dysfunction and was receiving a high dose of erythromycin. This interaction may occur with other macrolide antibiotics.

MANAGEMENT: The patient should be monitored for evidence of adverse effects such as nausea, vomiting, diarrhea, or abdominal pain. Ranitidine, nizatidine and famotidine do not inhibit CYP450 and would not be expected to affect erythromycin levels at recommended doses.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Mogford N, Pallett A, George C "Erythromycin deafness and cimetidine treatment." BMJ 309 (1994): 1620
"Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Axid (nizatidine)." Lilly, Eli and Company, Indianapolis, IN.

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

Tagamet HB

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet HB?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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