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PCE Dispertab and Tramadol ER

Determining the interaction of PCE Dispertab and Tramadol ER and the possibility of their joint administration.

Check result:
PCE Dispertab <> Tramadol ER
Relevance: 03.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Erythromycin may increase the blood levels and effects of traMADol. This can increase side effects such as nausea, constipation, dizziness, drowsiness, lightheadedness, difficulty concentrating, impairment in thinking and judgment, respiratory depression, and low blood pressure. You should avoid or limit the use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with drugs that are inhibitors of the CYP450 3A4 isoenzymes may increase the plasma concentrations of tramadol and its active O-demethylated metabolite. The risk of adverse effects including seizures and serotonin syndrome may be increased.

MANAGEMENT: Caution is advised if tramadol is used concomitantly with medications that inhibit CYP450 3A4 metabolism. Dosage adjustments as well as clinical monitoring may be appropriate whenever there drugs are added to or withdrawn from therapy.

References
  • Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
  • "Product Information. Ultram (tramadol)." McNeil Pharmaceutical, Raritan, NJ.
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

Tramadol ER

Generic Name: tramadol

Brand name: ConZip, Ultram, Ultram ER, Rybix ODT, Ryzolt

Synonyms: Tramadol, TraMADol

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction