PCE Dispertab and Vardenafil Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using vardenafil together with erythromycin. Combining these medications may significantly increase the blood levels and effects of vardenafil. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), as these may be signs and symptoms of excessive vardenafil levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with erythromycin or clarithromycin may significantly increase the plasma concentrations of vardenafil. The mechanism is inhibition of CYP450 3A4 by erythromycin and clarithromycin. CYP450 3A4 is the isoenzyme primarily responsible for the metabolic clearance of vardenafil. According to vardenafil labeling, coadministration of erythromycin (500 mg three times a day) and vardenafil (5 mg) resulted in a 3-fold increase in the peak plasma concentration (Cmax) and a 4-fold increase in the area under the concentration-time curve (AUC) of vardenafil. Similar effects on Cmax and AUC are expected with clarithromycin. The possibility of prolonged and/or increased pharmacologic effects of vardenafil should be considered. In addition, vardenafil has been reported to cause prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. The risk is dependent on underlying risk factors such as congenital long QT syndrome, cardiac disease, electrolyte disturbances (e.g., hypokalemia, hypomagnesemia), and concomitant use of multiple agents associated with QT interval prolongation.

MANAGEMENT: Some authorities recommend that patients treated with clarithromycin should not receive more than a single 2.5 mg dose of vardenafil within a 24-hour period and those treated with erythromycin should not receive more than a single 5 mg dose of vardenafil within a 24-hour period. Patients should be advised to promptly notify their physician if they experience pain or tightness in the chest or jaw, irregular heartbeat, nausea, shortness of breath, visual disturbances, syncope, or prolonged erection (greater than 4 hours).

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

Vardenafil Hydrochloride

Generic Name: vardenafil

Brand name: Levitra, Staxyn

Synonyms: Vardenafil

What is Vardenafil Hydrochloride?