Pedia-Lax Chewable and Sumatriptan and naproxen
Determining the interaction of Pedia-Lax Chewable and Sumatriptan and naproxen and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Antacids and some oral aluminum, calcium, or magnesium containing preparations may decrease the gastrointestinal absorption of enteric-coated naproxen, which requires an acidic environment for dissolution. The proposed mechanism is an increase in gastric pH (i.e. decreased gastric acidity) produced by antacids. In patients treated with antacids, the possibility of a reduced or subtherapeutic response to enteric-coated naproxen should be considered. Concomitant use of these drugs is generally not recommended. Aluminum hydroxide and some magnesium-containing antacids have also been reported to reduce the absorption of regular naproxen. The interaction may be minimized by separating the times of administration by at least 2 hours.
- Segre EJ, Sevelius H, Varady J "Effects of antacids on naproxen absorption." N Engl J Med 291 (1974): 582-3
- Brogden RN, Heel RC, Speight TM, Avery GS "Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states." Drugs 18 (1979): 241-77
Generic Name: magnesium hydroxide
Brand name: Ex-Lax Milk of Magnesia, Milk of Magnesia, Pedia-Lax Chewable, Phillips Milk of Magnesia, Dulcolax Milk of Magnesia, Concentrated Phillips Milk of Magnesia
Synonyms: n.a.
Generic Name: naproxen / sumatriptan
Brand name: Treximet
Synonyms: Sumatriptan and Naproxen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pedia-Lax Chewable-Sumatriptan injection
- Pedia-Lax Chewable-Sumatriptan Nasal Powder
- Pedia-Lax Chewable-Sumatriptan Nasal Spray
- Pedia-Lax Chewable-Sumatriptan Nasal, Oral, Subcutaneous
- Pedia-Lax Chewable-Sumatriptan oral/nasal
- Pedia-Lax Chewable-Sumatriptan Subcutaneous
- Sumatriptan and naproxen-Pedia-Lax Liquid rectal
- Sumatriptan and naproxen-Pediacare
- Sumatriptan and naproxen-PediaCare Children’s Multi-Symptom
- Sumatriptan and naproxen-PediaCare Cold/Allergy
- Sumatriptan and naproxen-Pediacare Decongestant Infants
- Sumatriptan and naproxen-Pediacare Long-Acting Cough