Pegademase bovine and Tibsovo

• Generic Name: pegademase bovine
• Dosage Forms: n.a.
• Other Brand Names: Adagen

Pegademase bovine is a man-made form of an enzyme called adenosine deaminase (ADA). ADA is important in the body for preventing the buildup of certain proteins harmful to the white blood cells that help your body fight infections.

Pegademase bovine is used to replace ADA in people with severe combined immunodeficiency disease (SCID).

Pegademase bovine may also be used for purposes not listed in this medication guide.

• Generic Name: ivosidenib
• Dosage Forms: tablet, film coated
• Other Brand Names: Tibsovo

Tibsovo (ivosidenib) targets a specific gene mutation called IDH1, which can affect your bone marrow. IDH1 mutation prevents young blood cells from developing into healthy adult blood cells, which can result in symptoms of acute myeloid leukemia.

Tibsovo is used to treat acute myeloid leukemia (AML).

Tibsovo is used to treat AML in adults with an IDH1 mutation. Your doctor will test you for this gene. Ivosidenib is used when other treatments did not work or have stopped working.

Tibsovo is also used in adults 75 years and older who have newly-diagnosed AML and cannot use certain chemotherapy treatments because of other health problems.