Pentobarbital injection and Tacrolimus
Determining the interaction of Pentobarbital injection and Tacrolimus and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PENTobarbital may reduce the blood levels of tacrolimus in some patients, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of sirolimus and tacrolimus, both of which are primarily metabolized by the isoenzyme.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant drug levels, caution is advised during concomitant therapy with CYP450 3A4 inducers. Sirolimus and tacrolimus blood levels should be checked frequently and the dosage adjusted accordingly whenever a CYP450 3A4 inducer is added to or withdrawn from therapy.
- "Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Pentobarbital (injection), PENTobarbital
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pentobarbital injection-Tacrolimus (Systemic)
- Pentobarbital injection-Tacrolimus Capsules
- Pentobarbital injection-Tacrolimus Extended-Release Capsules
- Pentobarbital injection-Tacrolimus Extended-Release Tablets
- Pentobarbital injection-Tacrolimus Granules for Suspension
- Pentobarbital injection-Tacrolimus Injection
- Tacrolimus-Pentobarbital Sodium
- Tacrolimus-Pentobarbital Sodium Injection
- Tacrolimus-Pentopak
- Tacrolimus-Pentosan polysulfate sodium
- Tacrolimus-Pentostatin
- Tacrolimus-Pentostatin Intravenous