Perampanel Oral Suspension and Phentermine and topiramate
Determining the interaction of Perampanel Oral Suspension and Phentermine and topiramate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Topiramate may increase the blood levels and effects of phentermine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects such as dizziness, restlessness, insomnia, tremor, headache, mood changes, palpitation, rapid heart beat, or blood pressure elevation. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with topiramate may increase the plasma concentrations of phentermine. The exact mechanism of interaction has not been established. When a single 15 mg dose of phentermine was administered with a 92 mg dose of topiramate, phentermine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 13% and 42%, respectively, compared to phentermine administered alone. No significant changes were observed in the pharmacokinetics of topiramate.
MANAGEMENT: Caution is advised when phentermine is used in combination with topiramate. Patients should be monitored for potentially increased adverse effects of phentermine such as dizziness, restlessness, insomnia, tremor, headache, euphoria, dysphoria, palpitation, tachycardia, and blood pressure elevation.
- "Product Information. Ionamin (phentermine)." Rhone-Poulenc Rorer, Collegeville, PA.
Generic Name: perampanel
Brand name: Fycompa
Synonyms: Perampanel
Generic Name: phentermine / topiramate
Brand name: Qsymia
Synonyms: Phentermine and Topiramate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Perampanel Oral Suspension-Phentermine Capsules
- Perampanel Oral Suspension-Phentermine Capsules and Tablets
- Perampanel Oral Suspension-Phentermine Extended Release
- Perampanel Oral Suspension-Phentermine Hydrochloride
- Perampanel Oral Suspension-Phentermine ODT Tablets
- Perampanel Oral Suspension-Phentermine Orally Disintegrating Tablets
- Phentermine and topiramate-Perampanel Tablets
- Phentermine and topiramate-Peranex HC
- Phentermine and topiramate-Percocet
- Phentermine and topiramate-Percocet 10/325
- Phentermine and topiramate-Percocet 2.5/325
- Phentermine and topiramate-Percocet 5/325