Perampanel Oral Suspension and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using perampanel together with carBAMazepine. Combining these medications may reduce the blood levels and effects of perampanel. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration of perampanel with other antiepileptic medications that are inducers of CYP450 3A4 may significantly decrease the plasma concentrations and pharmacologic effects of perampanel, which is primarily metabolized by the isoenzyme. Reductions in the average steady state concentrations of perampanel have been reported with known CYP450 3A4 inducers such as carbamazepine (3-fold decrease), oxcarbazepine (2-fold decrease), phenytoin (2-fold decrease), and topiramate (20% decrease). In addition, a 35% increase was reported in oxcarbazepine concentration; however, its active metabolite was not measured.

MANAGEMENT: Pharmacologic effects of perampanel should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the perampanel dosage adjusted as necessary according to the patient's clinical response.

Perampanel Oral Suspension

Generic Name: perampanel

Brand name: Fycompa

Synonyms: Perampanel

What is Perampanel Oral Suspension?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?