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Persantine and Rubex

Determining the interaction of Persantine and Rubex and the possibility of their joint administration.

Check result:

Persantine <> Rubex

Relevance: 07.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data have shown that dipyridamole can potentiate the cytotoxicity of doxorubicin. The synergy between dipyridamole and doxorubicin appears to be due to enhancement of intracellular doxorubicin accumulation by dipyridamole.

References

Kusumoto H, Maehara Y, Anai H, Kumashiro R, Sugimachi K "Dipyridamole potentiates adriamycin cytotoxicity by a mechanism other than inhibiting nucleoside uptake." Anticancer Res 11 (1991): 1539-42

Persantine

Generic Name: dipyridamole

Brand name: Persantine, Persantine IV

Synonyms: n.a.

What is Persantine?

Rubex

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: Doxorubicin, DOXOrubicin (Conventional)

What is Rubex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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