Pertuzumab Intravenous and Tiagabine Hydrochloride

• Generic Name: pertuzumab
• Dosage Forms: n.a.
• Other Brand Names: Perjeta

Pertuzumab injection is used to treat breast cancer that has spread to other parts of the body. It is used together with other cancer medicines (eg, docetaxel, trastuzumab) to treat patients with HER2-positive breast cancer. The HER2 protein is produced by some breast tumors. Pertuzumab is a monoclonal antibody that interferes with the growth of this protein, which is eventually destroyed by the body.

Pertuzumab is also used as part of a complete treatment regimen for early breast cancer before surgery and as an additional treatment for breast cancer that is at high risk for occurring again.

Pertuzumab is to be given only by or under the immediate supervision of your doctor.

• Generic Name: tiagabine
• Dosage Forms: n.a.
• Other Brand Names: Gabitril

Adjunctive therapy (i.e., in combination with other anticonvulsants) of partial seizures in adults and children ≥12 years of age.

Effective in reducing seizure frequency in patients with simple and/or complex partial seizures refractory to therapy with one or more conventional anticonvulsant drugs (e.g., carbamazepine, phenytoin, valproate).

Safety and efficacy for any indication other than the management of partial seizures not established; unlabeled (off-label) use has been associated with new-onset seizures, including status epilepticus. Use of tiagabine for unlabeled indications is strongly discouraged. (See Seizures in Nonepileptic Patients under Cautions.)