Pexidartinib Hydrochloride and Phenytoin Oral Suspension
Determining the interaction of Pexidartinib Hydrochloride and Phenytoin Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of pexidartinib with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of pexidartinib. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of pexidartinib. Concomitant administration of rifampin, a strong CYP450 3A4 inducer, decreased pexidartinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% and 65%, respectively. The effect of coadministration with a moderate CYP450 3A4 inducer on pexidartinib pharmacokinetics is unknown. MANAGEMENT: The use of pexidartinib with strong CYP450 3A4 inducers is not recommended. References "Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.
Professional:GENERALLY AVOID: Coadministration of pexidartinib with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of pexidartinib. The proposed mechanism is induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of pexidartinib. Concomitant administration of rifampin, a strong CYP450 3A4 inducer, decreased pexidartinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 33% and 65%, respectively. The effect of coadministration with a moderate CYP450 3A4 inducer on pexidartinib pharmacokinetics is unknown.
MANAGEMENT: The use of pexidartinib with strong CYP450 3A4 inducers is not recommended.
- "Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: pexidartinib
Brand name: Turalio
Synonyms: Pexidartinib
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pexidartinib Hydrochloride-Phenytoin Sodium
- Pexidartinib Hydrochloride-Phenytoin Sodium, Prompt injection
- Pexidartinib Hydrochloride-Phenytoin Suspension
- Pexidartinib Hydrochloride-Philith
- Pexidartinib Hydrochloride-Phillips Milk of Magnesia
- Pexidartinib Hydrochloride-Phisohex
- Phenytoin Oral Suspension-Pfizerpen
- Phenytoin Oral Suspension-Pharaon Tea
- Phenytoin Oral Suspension-Pharmorubicin Pfs
- Phenytoin Oral Suspension-Phazyme
- Phenytoin Oral Suspension-Phazyme Liquid Gas Relief, Maximum Strength
- Phenytoin Oral Suspension-Phena-Plus