Phenelzine Sulfate and Primaquine

• Generic Name: phenelzine
• Dosage Forms: n.a.
• Other Brand Names: Nardil

Treatment of major depressive disorder.

Phenelzine is effective in patients with depression clinically characterized as atypical, nonendogenous, or neurotic; these patients often have mixed anxiety and depression and phobic or hypochondriacal features. Less conclusive evidence that drug is useful in severely depressed patients with endogenous features.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.

Phenelzine has been used with some success in the management of bulimia nervosa.

However, MAO inhibitors are potentially dangerous (e.g., risk of hypertensive crisis) in patients with eating disorders and should be used with caution in patients with chaotic binge eating and purging behaviors. MAO inhibitors currently are not recommended as first-line therapy in the management of bulimia nervosa.

• Generic Name: primaquine
• Dosage Forms: n.a.
• Other Brand Names:

Primaquine is a medication to treat or prevent malaria, a disease caused by parasites. primaquine works by interfering with the growth of parasites in the body.

Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

Vivax malaria is a form of malaria in which parasites travel from the bloodstream into other cells and tissues of the body. This can cause a second infection (relapse) to occur.

Primaquine is used to prevent malaria from coming back in people who have been infected with the vivax form of this disease.

Primaquine may also be used for purposes not listed in this medication guide.