Phenelzine Sulfate and SymlinPen 120

• Generic Name: phenelzine
• Dosage Forms: n.a.
• Other Brand Names: Nardil

Treatment of major depressive disorder.

Phenelzine is effective in patients with depression clinically characterized as atypical, nonendogenous, or neurotic; these patients often have mixed anxiety and depression and phobic or hypochondriacal features. Less conclusive evidence that drug is useful in severely depressed patients with endogenous features.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.

Phenelzine has been used with some success in the management of bulimia nervosa.

However, MAO inhibitors are potentially dangerous (e.g., risk of hypertensive crisis) in patients with eating disorders and should be used with caution in patients with chaotic binge eating and purging behaviors. MAO inhibitors currently are not recommended as first-line therapy in the management of bulimia nervosa.

• Generic Name: pramlintide
• Dosage Forms: n.a.
• Other Brand Names: SymlinPen 120, SymlinPen 60, Symlin

SymlinPen 120 is a man-made form of a hormone that occurs naturally in the body. This medicine lowers blood sugar in three ways. It slows the rate that food moves from your stomach to your intestines, which keeps your blood sugar from rising too fast. This medicine also lowers the amount of glucose (sugar) your liver produces. Lastly, this medicine triggers the feeling of fullness after meals to help control your appetite and decrease how much food you eat.

SymlinPen 120 is used together with insulin to treat type 1 or type 2 diabetes. This medicine is usually given after other diabetes medicines have been tried without success.

SymlinPen 120 may also be used for purposes not listed in this medication guide.