Phenergan Suppositories and Phenytoin Extended-Release Capsules
Determining the interaction of Phenergan Suppositories and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking phenytoin, tell your doctor if you also use promethazine. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have symptoms of drowsiness, visual disturbances, change in mental status, seizures, and nausea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Concurrent use of phenothiazines and phenytoin may increase the effect of phenytoin and decrease the effect of the phenothiazine. The mechanism is unknown and clinical data have been inconsistent.
MANAGEMENT: Close monitoring for clinical and laboratory evidence of phenytoin toxicity is indicated. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.
- Vincent FM "Phenothiazine-induced phenytoin intoxication." Ann Intern Med 93 (1980): 56-7
- Linnoila M, Viukari M, Vaisanen K, Auvinen J "Effect of anticonvulsants on plasma haloperidol and thioridazine levels." Am J Psychiatry 137 (1980): 819-21
- Haidukewych D, Rodin EA "Effect of phenothiazines on serum antiepileptic drug concentrations in psychiatric patients with seizure disorder." Ther Drug Monit 7 (1985): 401-4
- Houghton GW, Richens A "Inhibition of phenytoin metabolism by other drugs used in epilepsy." Int J Clin Pharmacol 12 (1975): 210-6
- Sands CD, Robinson JD, Salem RB, Stewart RB, Muniz C "Effect of thioridazine on phenytoin serum concentration: a retrospective study." Drug Intell Clin Pharm 21 (1987): 267-72
Generic Name: promethazine
Brand name: Phenergan, Phenadoz, Promethegan
Synonyms: Phenergan
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenergan Suppositories-Phenytoin Infatabs
- Phenergan Suppositories-Phenytoin injection
- Phenergan Suppositories-Phenytoin Intravenous
- Phenergan Suppositories-Phenytoin Oral Suspension
- Phenergan Suppositories-Phenytoin Sodium
- Phenergan Suppositories-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Phenergan VC
- Phenytoin Extended-Release Capsules-Phenergan w/Codeine
- Phenytoin Extended-Release Capsules-Phenobarbital
- Phenytoin Extended-Release Capsules-Phenobarbital Elixir
- Phenytoin Extended-Release Capsules-Phenobarbital Injection
- Phenytoin Extended-Release Capsules-Phenobarbital Oral Solution