Phenobarbital and Synthroid Injection
Determining the interaction of Phenobarbital and Synthroid Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using PHENobarbital together with levothyroxine can decrease the effects of PHENobarbital. This can cause fatigue, weight gain, constipation, and low blood pressure. Talk with your doctor before using these medications together, and report any side effects promptly. You may need a dose adjustment or thyroid tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Barbiturates may decrease exogenous thyroid plasma concentrations resulting in elevated thyroid stimulating hormone (TSH) and exacerbation of hypothyroidism. The mechanism may be induction of hepatic CYP450 enzymes responsible for thyroxine (T4) and triiodothyronine (T3) metabolism. Clinical data are limited.
MANAGEMENT: Clinical monitoring of patient response, including laboratory serum TSH concentrations, is recommended. Adjustment of thyroid replacement dosage may be indicated when initiating or discontinuing barbiturate therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Multum Information Services, Inc. Expert Review Panel"
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: PHENobarbital
Generic Name: levothyroxine
Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol
Synonyms: Synthroid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenobarbital-Syntocinon
- Phenobarbital-Synvexia (Lidocaine and Menthol Cream)
- Phenobarbital-Synvexia (Lidocaine and Menthol Patch)
- Phenobarbital-Synvexia Patch
- Phenobarbital-Synvexia TC Cream
- Phenobarbital-Synvisc
- Synthroid Injection-Phenobarbital Elixir
- Synthroid Injection-Phenobarbital Injection
- Synthroid Injection-Phenobarbital Oral Solution
- Synthroid Injection-Phenobarbital Sodium
- Synthroid Injection-Phenobarbital Sodium Injection
- Synthroid Injection-Phenobarbital Tablets