Phenobarbital Elixir and Propafenone Tablets
Determining the interaction of Phenobarbital Elixir and Propafenone Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some barbiturates increase the hepatic metabolism of propafenone. Plasma levels and efficacy of propafenone may be decreased. Data are available for phenobarbital. Propafenone efficacy should be monitored during coadministration, and plasma propafenone levels should be checked as necessary. It may be necessary to increase propafenone dosage.
- Chan GL, Axelson JE, Kerr CR "The effect of phenobarbital on the pharmacokinetics of propafenone in man." Pharm Res 5 (1988): s153
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
Generic Name: propafenone
Brand name: Rythmol, Rythmol SR
Synonyms: Propafenone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenobarbital Elixir-Propantheline
- Phenobarbital Elixir-Propantheline Bromide
- Phenobarbital Elixir-Propecia
- Phenobarbital Elixir-Propel
- Phenobarbital Elixir-Propine
- Phenobarbital Elixir-Propofol
- Propafenone Tablets-Phenobarbital Injection
- Propafenone Tablets-Phenobarbital Oral Solution
- Propafenone Tablets-Phenobarbital Sodium
- Propafenone Tablets-Phenobarbital Sodium Injection
- Propafenone Tablets-Phenobarbital Tablets
- Propafenone Tablets-Phenobarbital with Belladonna Alkaloids Elixir