Phenobarbital Oral Solution and Propafenone Hydrochloride
Determining the interaction of Phenobarbital Oral Solution and Propafenone Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some barbiturates increase the hepatic metabolism of propafenone. Plasma levels and efficacy of propafenone may be decreased. Data are available for phenobarbital. Propafenone efficacy should be monitored during coadministration, and plasma propafenone levels should be checked as necessary. It may be necessary to increase propafenone dosage.
- Chan GL, Axelson JE, Kerr CR "The effect of phenobarbital on the pharmacokinetics of propafenone in man." Pharm Res 5 (1988): s153
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
Generic Name: propafenone
Brand name: Rythmol, Rythmol SR
Synonyms: Propafenone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenobarbital Oral Solution-Propafenone Sustained-Release Capsules
- Phenobarbital Oral Solution-Propafenone Tablets
- Phenobarbital Oral Solution-Propantheline
- Phenobarbital Oral Solution-Propantheline Bromide
- Phenobarbital Oral Solution-Propecia
- Phenobarbital Oral Solution-Propel
- Propafenone Hydrochloride-Phenobarbital Sodium
- Propafenone Hydrochloride-Phenobarbital Sodium Injection
- Propafenone Hydrochloride-Phenobarbital Tablets
- Propafenone Hydrochloride-Phenobarbital with Belladonna Alkaloids Elixir
- Propafenone Hydrochloride-Phenohytro
- Propafenone Hydrochloride-Phenohytro Elixir