Phenobarbital Sodium Injection and Vibramycin Hyclate
Determining the interaction of Phenobarbital Sodium Injection and Vibramycin Hyclate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using doxycycline and PHENobarbital. Alternative antibiotic therapy, if available, is generally recommended. You may need a doxycycline dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Barbiturates may decrease serum concentrations and half-life of oral doxycycline to subtherapeutic levels. The mechanism may be induction of the hepatic metabolism of doxycycline.
MANAGEMENT: Other tetracyclines which are primarily renally excreted (e.g., tetracycline, demeclocycline, oxytetracycline) should be considered, as they are not expected to interact. If the patient must receive doxycycline, close monitoring for altered efficacy is recommended.
- Neuvonen PJ, Penttila O, Lehtovaara R, Aho K "Effect of antiepileptic drugs on the elimination of various tetracycline derivatives." Eur J Clin Pharmacol 9 (1975): 147-54
- Neuvonen PJ, Penttila O "Interaction between doxycycline and barbiturates." Br Med J 1 (1974): 535-6
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
Generic Name: doxycycline
Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX
Synonyms: Doxycycline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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