Phenoxybenzamine Hydrochloride and Pyrophosphate Injection

• Generic Name: phenoxybenzamine
• Dosage Forms: n.a.
• Other Brand Names: Dibenzyline

Prevention or treatment of paroxysmal hypertension and sweating in patients with pheochromocytoma.

Considered drug of choice for medical management of pheochromocytoma until surgery is performed and for prolonged treatment of hypertension caused by pheochromocytoma notamenable to surgery.

Used in conjunction with a β-adrenergic blocking agent (propranolol) to control symptoms from excessive β-receptor stimulation in patients with inoperable or metastatic pheochromocytoma or to control tachycardia prior to or during pheochromocytomectomy. (See General under Dosage and Administration.)

Has been used as adjunctive therapy in the treatment of peripheral vasospastic disorders associated with increased α-adrenergic activity (e.g., Raynaud’s syndrome, acrocyanosis, and frostbite sequelae) but efficacy in the treatment of peripheral vascular disease is not established.

Phenoxybenzamine should not be used in diseases affecting large blood vessels.

Has been used in the treatment of micturition disorders resulting from neurogenic bladder, functional outlet obstruction, or partial prostatic obstruction.

Has been used for the prevention and treatment of acute postoperative urinary retention, including that associated with the use of epidural morphine.

• Generic Name: pyrophosphate
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Technescan PYP

• It is used with a special imaging test.