Phentolamine Mesylate and Vivelle 37.5 Mcg

• Generic Name: phentolamine
• Dosage Forms: n.a.
• Other Brand Names: OraVerse

Used as an aid in the diagnosis of pheochromocytoma.

Determination of blood catecholamine concentrations, urinary assay of catecholamines, or other biochemical assays are the safest and most reliable diagnostic methods and they have largely replaced phentolamine and other pharmaceutical tests. No test, however, is completely reliable.

May be used when additional confirmatory evidence of pheochromocytoma is required and potential benefits outweigh the possible risks.

Test is more reliable with sustained than with paroxysmal hypertension; no diagnostic value in absence of hypertension at the time of the test.

Sudden and marked reduction in BP following parenteral administration of phentolamine suggests pheochromocytoma; however, false-negative and false-positive responses are frequent.

May be administered immediately prior to or during pheochromocytomectomy to prevent or control paroxysmal hypertension resulting from anesthesia, stress, or operative manipulation of the tumor.

Has been used to manage pheochromocytoma until surgery is performed and for prolonged treatment of hypertension when the tumor is not operable; however, phenoxybenzamine is considered the drug of choice because it has a longer duration of action.

Has been used in the treatment of hypertensive emergencies (severe elevations in BP >180/120 mm Hg accompanied by new or worsening target organ dysfunction) induced by catecholamine excess (e.g., pheochromocytoma, drug interactions with an MAO inhibitor, amphetamine overdosage, cocaine toxicity, clonidine withdrawal).

Used to prevent dermal necrosis and sloughing following IV administration or extravasation of norepinephrine.

Has been used to prevent necrosis after extravasation of dopamine.

Has been used to decrease impedance to left ventricular ejection and the infarct size in patients with MI associated with left ventricular failure.

However, contraindicated in patients with MI, and investigators do not recommend for routine use, since left ventricular function and the ECG must be monitored continuously.

Self-injection of small doses combined with papaverine hydrochloride into the corpus cavernosum has been effective for the treatment of erectile dysfunction (ED, impotence).

Combination has been effective in patients with neurogenic and/or limited vasculogenic impotence or with psychogenic impotence, but efficacy in those with a vasculogenic component of their impotence may be variable depending on the extent and type of vascular dysfunction.

Erection, which can be potentiated by sexual arousal, usually occurs within 10 minutes after injection of the drugs and may persist for 1 to several hours; tolerance to the drugs may occur during long-term use; priapism may occur.

Has been used as an adjunct in the management of cocaine overdose to reverse coronary vasoconstriction.

• Generic Name: estradiol
• Dosage Forms: n.a.
• Other Brand Names: Estrace, Vivelle-Dot, Vivelle, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estraderm, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Climara, Estradiol Patch, Depo-Estradiol, Elestrin Pump, EstroGel Pump, Femring, Gynodiol

Estradiol transdermal gel, patch, and spray are used to treat moderate to severe hot flashes and other symptoms of menopause or low amounts of estrogen. It is also used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. This medicine is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogens naturally, and prevent osteoporosis after menopause.

Estradiol is an estrogen hormone. The hormone from the patch, gel, and spray is absorbed through your skin into your body. It works by preventing symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (hot flashes) in women during menopause.

This medicine is available only with your doctor's prescription.