Phenytek and Sarafem Tablets
Determining the interaction of Phenytek and Sarafem Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking phenytoin, tell your doctor if you also use FLUoxetine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase the phenytoin levels in your body. You should notify your doctor if you have symptoms such as drowsiness, visual problems, seizures, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Fluoxetine may increase serum hydantoin levels. The mechanism is unknown, but may be related to inhibition of hepatic CYP450 2C9 and 2C19 hydantoin metabolism.
MANAGEMENT: Close observation for clinical and laboratory evidence of hydantoin toxicity is recommended if these drugs must be used together. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.
- Jalil P "Toxic reaction following the combined administration of fluoxetine and phenytoin: two case reports." J Neurol Neurosurg Psychiatry 55 (1992): 412-3
- Nightingale SL "Fluoxetine labeling revised to identify phenytoin interaction and to recommend against use in nursing mothers." JAMA 271 (1994): 1067
- Shader RI, Greenblatt DJ, Vonmoltke LL "Fluoxetine inhibition of phenytoin metabolism." J Clin Psychopharmacol 14 (1994): 375-6
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: n.a.
Generic Name: fluoxetine
Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra
Synonyms: FLUoxetine, Fluoxetine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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