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Phenytoin Capsules and Xarelto

Determining the interaction of Phenytoin Capsules and Xarelto and the possibility of their joint administration.

Check result:

Phenytoin Capsules <> Xarelto

Relevance: 23.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Phenytoin may reduce the blood levels of rivaroxaban, which may make the medication less effective in preventing blood clots. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of rivaroxaban, which is a substrate of the isoenzyme. In a pharmacokinetic study, administration of a single 20 mg dose of rivaroxaban with the potent CYP450 3A4 inducer rifampin (titrated up to 600 mg once daily) resulted in approximately 22% and 50% decreases in mean rivaroxaban peak plasma concentration (Cmax) and system exposure (AUC), respectively, with parallel decreases in its pharmacodynamic effects.

MANAGEMENT: Concomitant use of rivaroxaban with potent CYP450 3A4 inducers should generally be avoided.

References

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Xarelto (rivaroxaban)." Bayer Inc, Toronto, IA.

Phenytoin Capsules

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Capsules?

Xarelto

Generic Name: rivaroxaban

Brand name: Xarelto, Xarelto Starter Pack

Synonyms: n.a.

What is Xarelto?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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