Phenytoin Chewable Tablets and Walgreens Ibuprofen Junior Strength
Determining the interaction of Phenytoin Chewable Tablets and Walgreens Ibuprofen Junior Strength and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One case report has suggested that ibuprofen may cause phenytoin toxicity. However, data have been conflicting: one pharmacokinetic study did not demonstrate an effect and another study demonstrated that ibuprofen displaces phenytoin from protein binding sites in vitro. The clinical significance is unknown. Clinical and laboratory monitoring for altered phenytoin effect is recommended.
- Bachmann KA, Schwartz JI, Forney RB Jr, et al "Inability of ibuprofen to alter single dose phenytoin disposition." Br J Clin Pharmacol 21 (1986): 165-9
- Sandyk R "Phenytoin toxicity induced by interaction with ibuprofen." S Afr Med J 62 (1982): 592
- Dasgupta A, Timmerman TG "In vitro displacement of phenytoin from protein binding by nonsteroidal antiinflammatory drugs tolmetin, ibuprofen, and naproxen in normal and uremic sera." Ther Drug Monit 18 (1996): 97-9
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
Generic Name: ibuprofen
Brand name: Advil, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Advil Liqui-Gels, Caldolor, NeoProfen, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength
Synonyms: Ibuprofen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Chewable Tablets-Warfarin
- Phenytoin Chewable Tablets-Warfarin Sodium
- Phenytoin Chewable Tablets-Wart Remover
- Phenytoin Chewable Tablets-Wart-Off Maximum Strength Topical
- Phenytoin Chewable Tablets-Wee Care
- Phenytoin Chewable Tablets-Welby Health Allergy Relief
- Walgreens Ibuprofen Junior Strength-Phenytoin Extended-Release Capsules
- Walgreens Ibuprofen Junior Strength-Phenytoin Infatabs
- Walgreens Ibuprofen Junior Strength-Phenytoin injection
- Walgreens Ibuprofen Junior Strength-Phenytoin Intravenous
- Walgreens Ibuprofen Junior Strength-Phenytoin Oral Suspension
- Walgreens Ibuprofen Junior Strength-Phenytoin Sodium