Phenytoin Chewable Tablets and Zofran injection
Determining the interaction of Phenytoin Chewable Tablets and Zofran injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using phenytoin together with ondansetron can decrease the effects of ondansetron. Contact your doctor if you experience an increase in nausea and vomiting. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of CYP450 3A4 inducers with ondansetron may result in a reduced antiemetic effect, particularly after the oral administration of ondansetron. The proposed mechanism is induction of the CYP450 3A4 mediated metabolism of ondansetron. The clinical significance is unknown.
MANAGEMENT: Patients should be monitored for reduced antiemetic effects and the ondansetron dose adjusted as necessary.
- "Multum Information Services, Inc. Expert Review Panel"
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
Generic Name: ondansetron
Brand name: Zofran, Zofran ODT, Zuplenz
Synonyms: Zofran
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Chewable Tablets-Zofran ODT
- Phenytoin Chewable Tablets-Zofran ODT Oral, Oromucosal
- Phenytoin Chewable Tablets-Zofran Oral, Oromucosal
- Phenytoin Chewable Tablets-Zohydro ER
- Phenytoin Chewable Tablets-Zohydro ER Capsules
- Phenytoin Chewable Tablets-Zoladex
- Zofran injection-Phenytoin Extended-Release Capsules
- Zofran injection-Phenytoin Infatabs
- Zofran injection-Phenytoin injection
- Zofran injection-Phenytoin Intravenous
- Zofran injection-Phenytoin Oral Suspension
- Zofran injection-Phenytoin Sodium