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Phenytoin Extended-Release Capsules and Tolazamide

Determining the interaction of Phenytoin Extended-Release Capsules and Tolazamide and the possibility of their joint administration.

Check result:

Phenytoin Extended-Release Capsules <> Tolazamide

Relevance: 11.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with TOLAZamide can make TOLAZamide less effective. This could make it harder for TOLAZamide to effectively control your blood sugar levels. Talk with your doctor before using phenytoin together with TOLAZamide. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The coadministration with phenytoin may diminish the hypoglycemic effect of sulfonylureas. Phenytoin has been reported to cause hyperglycemia, hypoinsulinemia and glucose intolerance, thus it may interfere with blood glucose control. Conversely, some sulfonylureas may enhance the plasma concentrations and pharmacologic effects of phenytoin by competitive inhibition of its metabolism by CYP450 2C9 and/or 2C19 isoenzymes. Phenytoin intoxication has been reported during coadministration with tolbutamide specifically.

MANAGEMENT: Consideration should be given to more closely monitoring blood glucose and phenytoin levels during coadministration with sulfonylureas. Patients should be advised to notify their physician if loss of glycemic control occurs or if they experience symptoms of possible phenytoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, and ataxia.

References

Stambaugh JE, Tucker DC "Effect of diphenylhydantoin on glucose tolerance in patients with hypoglycemia." Diabetes 23 (1974): 679-83
Malherbe C, Burrill KC, Levin SR, Karam JH, Forsham PH "Effect of diphenylhydantoin on insulin secretion in man." N Engl J Med 286 (1972): 339-42
Beech E, Mathur SV, Harrold BP "Phenytoin toxicity produced by tolbutamide." Br Med J 297 (1988): 1613-4
Tassaneeyakul W, Veronese ME, Birkett VDJ, et al. "Co-regulation of phenytoin and tolbutamide metabolism in humans." Br J Clin Pharmacol 34 (1992): 494-8
Carter BL, Small RE, Mandel MD, Starkman MT "Phenytoin-induced hyperglycemia." Am J Hosp Pharm 38 (1981): 1508-12
Al-Rubeaan K, Ryan EA "Phenytoin-induced insulin insensitivity." Diabet Med 8 (1991): 968-70

Phenytoin Extended-Release Capsules

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Extended-Release Capsules?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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