Phenytoin Extended-Release Capsules and Topamax (Topiramate Sprinkle Capsules)
Determining the interaction of Phenytoin Extended-Release Capsules and Topamax (Topiramate Sprinkle Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking phenytoin, tell your doctor if you also use topiramate. You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect the phenytoin and topiramate levels in your body. You should notify your doctor if you have symptoms such as drowsiness, visual disturbances, seizures, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Topiramate administered with phenytoin has been reported to have led to a 25% increase in phenytoin plasma concentrations, particularly in those patients receiving phenytoin twice a day. Additionally, the concentration of topiramate decreased by 48%. Topiramate may decrease the metabolism of phenytoin (or other hydantoins) while hydantoins may increase the metabolism of topiramate.
MANAGEMENT: Patients should be closely observed for clinical response and signs of hydantoin toxicity if these drugs must be given concurrently and serum concentrations should be monitored. Patients should be advised to notify their physician if they experience loss of seizure control or symptoms of hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia. Addition or withdrawal of hydantoins during therapy with topiramate may require a dose adjustment of topiramate and/or the hydantoin.
- "Product Information. Topamax (topiramate)." Ortho Pharmaceutical Corporation, Raritan, NJ.
- Bourgeois BF "Drug interaction profile of topiramate." Epilepsia 37(suppl 2 (1996): s14-7
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
Generic Name: topiramate
Brand name: Qudexy XR, Topamax, Topamax Sprinkle, Topiragen, Trokendi XR, Qudexy XR Sprinkle
Synonyms: Topamax
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Extended-Release Capsules-Topamax (Topiramate Tablets)
- Phenytoin Extended-Release Capsules-Topamax Sprinkle
- Phenytoin Extended-Release Capsules-Topcare 8 Hour Pain Relief
- Phenytoin Extended-Release Capsules-Topcare Acid Reducer
- Phenytoin Extended-Release Capsules-Topcare All Day Allergy D
- Phenytoin Extended-Release Capsules-Topcare All Day Pain Relief
- Topamax (Topiramate Sprinkle Capsules)-Phenytoin Infatabs
- Topamax (Topiramate Sprinkle Capsules)-Phenytoin injection
- Topamax (Topiramate Sprinkle Capsules)-Phenytoin Intravenous
- Topamax (Topiramate Sprinkle Capsules)-Phenytoin Oral Suspension
- Topamax (Topiramate Sprinkle Capsules)-Phenytoin Sodium
- Topamax (Topiramate Sprinkle Capsules)-Phenytoin Sodium, Prompt injection