Phenytoin Extended-Release Capsules and Xylocaine HCl
Determining the interaction of Phenytoin Extended-Release Capsules and Xylocaine HCl and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Hydantoins may increase the hepatic metabolism of intravenous lidocaine. Serum lidocaine levels may be decreased, and increased dosage may be necessary. Caution is recommended, however, since the possible myocardial-depressant effects of both drugs may be additive. Hemodynamic and electrocardiographic status should be monitored during therapy. No action is required unless an interaction is suspected.
- Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95
- Wood RA "Sinoatrial arrest: an interaction between phenytoin and lignocaine." Br Med J 1 (1971): 645
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Extended-Release Capsules-Xylocaine Jelly
- Phenytoin Extended-Release Capsules-Xylocaine MPF
- Phenytoin Extended-Release Capsules-Xylocaine MPF With Epinephrine
- Phenytoin Extended-Release Capsules-Xylocaine Topical application
- Phenytoin Extended-Release Capsules-Xylocaine Topical Solution
- Phenytoin Extended-Release Capsules-Xylocaine With Epinephrine
- Xylocaine HCl-Phenytoin Infatabs
- Xylocaine HCl-Phenytoin injection
- Xylocaine HCl-Phenytoin Intravenous
- Xylocaine HCl-Phenytoin Oral Suspension
- Xylocaine HCl-Phenytoin Sodium
- Xylocaine HCl-Phenytoin Sodium, Prompt injection