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Phenytoin Sodium and Stalevo 100

Determining the interaction of Phenytoin Sodium and Stalevo 100 and the possibility of their joint administration.

Check result:
Phenytoin Sodium <> Stalevo 100
Relevance: 26.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with levodopa may decrease the effects of levodopa. Contact your doctor if your condition changes or if you experience a worsening of your parkinsonian symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Phenytoin may decrease the therapeutic effects of levodopa. One small study has suggested that administration of phenytoin may exacerbate the rigidity and hypokinesia of patients with Parkinson's disease. The mechanism of this interaction is not known.

MANAGEMENT: If phenytoin and levodopa must be used together, close observation for evidence of altered levodopa effects is recommended. Patients should be advised to notify their physician if they experience a worsening of their parkinsonian symptoms. Levodopa dosage increases or alternatives to phenytoin may be required if evidence of an interaction is observed.

References
  • Mendez JS, Cotzias GC, Mena I, Papavasiliou PS "Diphenylhydantoin. Blocking of levodopa effects." Arch Neurol 32 (1975): 44-6
Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

Stalevo 100

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction