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Phenytoin Sodium and Sulfamethoxazole and Trimethoprim Tablets

Determining the interaction of Phenytoin Sodium and Sulfamethoxazole and Trimethoprim Tablets and the possibility of their joint administration.

Check result:

Phenytoin Sodium <> Sulfamethoxazole and Trimethoprim Tablets

Relevance: 26.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with trimethoprim may increase the effects of phenytoin. Contact your doctor if you experience twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Trimethoprim may inhibit the CYP450 hepatic metabolism of hydantoins. Serum hydantoin levels and risk of toxicity may be increased. Data are available for phenytoin.

MANAGEMENT: Monitoring for clinical and laboratory evidence of hydantoin toxicity is recommended. Dose adjustments may be necessary. Patients should be advised to notify their physician if they experience symptoms of hydantoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).

References

Gillman MA "Phenytoin toxicity and co-trimazole." Ann Intern Med 102 (1985): 559
Hansen JM, Kampmann JP, Siersback-Nielsen K, et al. "The effect of different sulfonamides on phenytoin metabolism in man." Acta Med Scand Suppl 624 (1979): 106-10

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

Sulfamethoxazole and Trimethoprim Tablets

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: Sulfamethoxazole and trimethoprim, Sulfamethoxazole and Trimethoprim

What is Sulfamethoxazole and Trimethoprim Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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