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Phenytoin Sodium and Sulfisoxazole

Determining the interaction of Phenytoin Sodium and Sulfisoxazole and the possibility of their joint administration.

Check result:

Phenytoin Sodium <> Sulfisoxazole

Relevance: 26.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with sulfiSOXAZOLE may increase the effects of phenytoin. Contact your doctor if you experience twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some sulfonamides may inhibit the hepatic metabolism of hydantoins. Serum hydantoin levels and risk of toxicity may be increased. Data are available for sulfadiazine, sulfaphenazole, and sulfamethizole.

MANAGEMENT: Monitoring for clinical and laboratory evidence of altered efficacy and safety is recommended. Hydantoin dosage adjustments or an alternate antimicrobial may be required if an interaction is suspected. Patients should be advised to notify their physician if they experience symptoms of hydantoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).

References

Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM "Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism." Clin Pharmacol Ther 17 (1975): 731-4
Hansen JM, Kampmann JP, Siersback-Nielsen K, et al. "The effect of different sulfonamides on phenytoin metabolism in man." Acta Med Scand Suppl 624 (1979): 106-10

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

Sulfisoxazole

Generic Name: sulfisoxazole

Brand name:

Synonyms: Sulfisoxazole (Oral)

What is Sulfisoxazole?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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