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Phenytoin Sodium and Xylocaine (Lidocaine Injection Solution (Anesthetic))

Determining the interaction of Phenytoin Sodium and Xylocaine (Lidocaine Injection Solution (Anesthetic)) and the possibility of their joint administration.

Check result:

Phenytoin Sodium <> Xylocaine (Lidocaine Injection Solution (Anesthetic))

Relevance: 26.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Hydantoins may increase the hepatic metabolism of intravenous lidocaine. Serum lidocaine levels may be decreased, and increased dosage may be necessary. Caution is recommended, however, since the possible myocardial-depressant effects of both drugs may be additive. Hemodynamic and electrocardiographic status should be monitored during therapy. No action is required unless an interaction is suspected.

References

Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95
Wood RA "Sinoatrial arrest: an interaction between phenytoin and lignocaine." Br Med J 1 (1971): 645

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

Xylocaine (Lidocaine Injection Solution (Anesthetic))

Generic Name: lidocaine

Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine

Synonyms: Lidocaine injection, Lidocaine (Systemic)

What is Xylocaine (Lidocaine Injection Solution (Anesthetic))?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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