Phenytoin Sodium, Prompt injection and Prelidopine Pre-Operative System
Determining the interaction of Phenytoin Sodium, Prompt injection and Prelidopine Pre-Operative System and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Hydantoins may increase the hepatic metabolism of intravenous lidocaine. Serum lidocaine levels may be decreased, and increased dosage may be necessary. Caution is recommended, however, since the possible myocardial-depressant effects of both drugs may be additive. Hemodynamic and electrocardiographic status should be monitored during therapy. No action is required unless an interaction is suspected.
- Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95
- Wood RA "Sinoatrial arrest: an interaction between phenytoin and lignocaine." Br Med J 1 (1971): 645
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine injection, Lidocaine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Sodium, Prompt injection-Prelone
- Phenytoin Sodium, Prompt injection-Prelu-2
- Phenytoin Sodium, Prompt injection-Premarin
- Phenytoin Sodium, Prompt injection-Premarin (Conjugated Estrogens Injection)
- Phenytoin Sodium, Prompt injection-Premarin (Conjugated Estrogens Tablets)
- Phenytoin Sodium, Prompt injection-Premarin (Estrogens (Conjugated/Equine, Topical))
- Prelidopine Pre-Operative System-Phenytoin Suspension
- Prelidopine Pre-Operative System-Philith
- Prelidopine Pre-Operative System-Phillips Milk of Magnesia
- Prelidopine Pre-Operative System-Phisohex
- Prelidopine Pre-Operative System-Phl-Fluoxetine
- Prelidopine Pre-Operative System-Phlemex